Microtubule Affinity Regulating Kinase Activity in Living Neurons Was Examined by a Genetically Encoded Fluorescence Resonance Energy Transfer/Fluorescence Lifetime Imaging-based Biosensor
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چکیده
Thomas Timm, Jens Peter von Kries, Xiaoyu Li, Hans Zempel, Eckhard Mandelkow, and Eva-Maria Mandelkow From the Max-Planck-Unit for Structural Molecular Biology, c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany, FMP, Forschungsinstitut fuer Molekulare Pharmakologie, Robert-Roessle-Strasse 10, 13125 Berlin, Germany, and the DZNE (German Center for Neurodegenerative Diseases) and CAESAR (Center of Advanced European Studies and Research) , Ludwig-Erhard-Allee 2, 53175 Bonn, Germany
منابع مشابه
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
Protein kinases of the microtubule affinity regulating kinase (MARK)/Par-1 family play important roles in the establishment of cellular polarity, cell cycle control, and intracellular signal transduction. Disturbance of their function is linked to cancer and brain diseases, e.g. lissencephaly and Alzheimer disease. To understand the biological role of MARK family kinases, we searched for specif...
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تاریخ انتشار 2011